大鼠黏液样或巨细胞亚型恶性纤维组织细胞瘤的转移潜能
Metastatic potential of malignant fibrous histiocytoma of myxoid or giant-cell subtype in rats.
作者信息
Miyauchi Y, Mii Y, Hohnoki K, Tamai S, Maruyama H, Tsutsumi M, Shiraiwa K, Konishi Y
机构信息
Department of Orthopedic Surgery, Nara Medical College, Japan.
出版信息
Exp Pathol. 1991;43(3-4):129-39. doi: 10.1016/s0232-1513(11)80106-4.
We have previously reported on the induction of rat malignant fibrous histiocytomas by 4-hydroxiaminoquinoline 1-oxide. The present study describes cell number- and time-related formation of metastatic lung nodules after i.v. injection of cell suspensions containing various numbers (10(3) to 10(5)/ml) of myxoid or giant-cell subtype malignant fibrous histiocytoma cells. The metastatic potential of the myxoid subtype of rat malignant fibrous histiocytoma was significantly enhanced by i.v. injection of tumor cells selected from metastatic lung nodules and was further increased by repeating the selection procedure more than 7 times. In contrast, the growth activity of subcutaneous transplants of tumor fragments obtained from metastatic lung nodules derived from myxoid subtype did not differ from that of parent malignant fibrous histiocytomas.
我们之前曾报道过4-羟基氨基喹啉1-氧化物可诱导大鼠发生恶性纤维组织细胞瘤。本研究描述了静脉注射含有不同数量（10³至10⁵/ml）黏液样或巨细胞亚型恶性纤维组织细胞瘤细胞的细胞悬液后，与细胞数量和时间相关的肺转移结节的形成情况。通过静脉注射从肺转移结节中选取的肿瘤细胞，大鼠恶性纤维组织细胞瘤黏液样亚型的转移潜能显著增强，且通过重复选取程序7次以上，转移潜能进一步提高。相比之下，从黏液样亚型的肺转移结节中获取的肿瘤片段皮下移植后的生长活性与亲本恶性纤维组织细胞瘤并无差异。
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