• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大麦（Hordeum vulgare L.）中的赖氨酸分解代谢

Lysine Catabolism in Barley (Hordeum vulgare L.).

作者信息

Møller B L

机构信息

Department of Chemistry, Royal Veterinary and Agricultural University, DK 1871 Copenhagen V, Denmark.

出版信息

Plant Physiol. 1976 May;57(5):687-92. doi: 10.1104/pp.57.5.687.

DOI:10.1104/pp.57.5.687
PMID:16659552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC542100/
Abstract

Lysine catabolism in seedlings of barley (Hordeum vulgare L. var. Emir) was studied by direct injection of the following tracers into the endosperm of the seedlings: aspartic acid-3-(14)C, 2-aminoadipic acid-1-(14)C, saccharopine-(14)C, 2,6-diaminopimelic acid-1-(7)-(14)C, and lysine-1-(14)C. Labeled saccharopine was formed only after the administration of either labeled 2,6-diaminopimelic acid or labeled lysine to the seedlings. The metabolic fate of the other tracers administered also supported a catabolic lysine pathway via saccharopine, and apparently proceeding by a reversal of some of the biosynthetic steps of the 2-aminoadipic acid pathway known from lysine biosynthesis in most fungi. Pipecolic acid seems not to be on the main pathway of l-lysine catabolism in barley seedlings.

摘要

通过向大麦（Hordeum vulgare L. var. Emir）幼苗胚乳中直接注射以下示踪剂，研究了其赖氨酸分解代谢：天冬氨酸-3-(14)C、2-氨基己二酸-1-(14)C、酵母氨酸-(14)C、2,6-二氨基庚二酸-1-(7)-(14)C和赖氨酸-1-(14)C。仅在向幼苗施用标记的2,6-二氨基庚二酸或标记的赖氨酸后，才形成标记的酵母氨酸。所施用的其他示踪剂的代谢命运也支持通过酵母氨酸的赖氨酸分解代谢途径，并且显然是通过逆转大多数真菌赖氨酸生物合成中已知的2-氨基己二酸途径的一些生物合成步骤进行的。哌啶酸似乎不在大麦幼苗L-赖氨酸分解代谢的主要途径上。

相似文献

1
Lysine Catabolism in Barley (Hordeum vulgare L.).大麦（Hordeum vulgare L.）中的赖氨酸分解代谢
Plant Physiol. 1976 May;57(5):687-92. doi: 10.1104/pp.57.5.687.
2
Lysine Biosynthesis in Barley (Hordeum vulgare L.).大麦（Hordeum vulgare L.）中的赖氨酸生物合成。
Plant Physiol. 1974 Oct;54(4):638-43. doi: 10.1104/pp.54.4.638.
3
Catabolism of lysine in Penicillium chrysogenum leads to formation of 2-aminoadipic acid, a precursor of penicillin biosynthesis.产黄青霉中赖氨酸的分解代谢导致2-氨基己二酸的形成，2-氨基己二酸是青霉素生物合成的前体。
Appl Environ Microbiol. 1994 Jun;60(6):1705-10. doi: 10.1128/aem.60.6.1705-1710.1994.
4
Role of pipecolic acid in the biosynthesis of lysine in Rhodotorula glutinis.哌啶酸在粘红酵母赖氨酸生物合成中的作用。
J Bacteriol. 1979 May;138(2):410-7. doi: 10.1128/jb.138.2.410-417.1979.
5
The saccharopine pathway in seed development and stress response of maize.玉米种子发育和胁迫响应中的酵母氨酸途径。
Plant Cell Environ. 2015 Nov;38(11):2450-61. doi: 10.1111/pce.12563. Epub 2015 Jul 16.
6
New insights into human lysine degradation pathways with relevance to pyridoxine-dependent epilepsy due to antiquitin deficiency.与人赖氨酸降解途径相关的新见解与抗坏血酸缺乏引起的依赖吡哆醇的癫痫有关。
J Inherit Metab Dis. 2019 Jul;42(4):620-628. doi: 10.1002/jimd.12076. Epub 2019 Apr 15.
7
Inactivation of the lys7 gene, encoding saccharopine reductase in Penicillium chrysogenum, leads to accumulation of the secondary metabolite precursors piperideine-6-carboxylic acid and pipecolic acid from alpha-aminoadipic acid.在产黄青霉中，编码酵母氨酸还原酶的lys7基因失活，导致次生代谢物前体哌啶-6-羧酸和哌可酸从α-氨基己二酸积累。
Appl Environ Microbiol. 2004 Feb;70(2):1031-9. doi: 10.1128/AEM.70.2.1031-1039.2004.
8
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. I. The lysine saccharopine, delta 1-piperideine-6-carboxylic acid pathway.豆科丝核菌中哌啶酸的生物合成。I. 赖氨酸糖基化途径、δ1-哌啶-6-羧酸途径。
J Biol Chem. 1990 Sep 5;265(25):14742-7.
9
Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE).鼠赖氨酸分解代谢为氨基己二酸主要通过 saccharopine 途径进行；对吡哆醇依赖性癫痫（PDE）的影响。
Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):121-128. doi: 10.1016/j.bbadis.2016.09.006. Epub 2016 Sep 8.
10
Simultaneous detection of lysine metabolites by a single LC-MS/MS method: monitoring lysine degradation in mouse plasma.采用单一液相色谱-串联质谱法同时检测赖氨酸代谢产物：监测小鼠血浆中赖氨酸的降解情况
Springerplus. 2016 Feb 25;5:172. doi: 10.1186/s40064-016-1809-1. eCollection 2016.

引用本文的文献

1
Membrane Filtration-Assisted Enzymatic Hydrolysis Affects the Biological Activity of Potato Juice.膜过滤辅助酶解对马铃薯汁生物活性的影响。
Molecules. 2021 Feb 6;26(4):852. doi: 10.3390/molecules26040852.
2
Metabolic changes in Avena sativa crowns recovering from freezing.从冻害中恢复的燕麦冠部的代谢变化。
PLoS One. 2014 Mar 27;9(3):e93085. doi: 10.1371/journal.pone.0093085. eCollection 2014.
3
Partial purification and characterization of lysine-ketoglutarate reductase in normal and opaque-2 maize endosperms.正常和 opaque-2 玉米胚乳中赖氨酸-酮戊二酸还原酶的部分纯化和性质鉴定。
Plant Physiol. 1992 Mar;98(3):1139-47. doi: 10.1104/pp.98.3.1139.
4
Lysine-ketoglutarate reductase activity in developing maize endosperm.赖氨酸-酮戊二酸还原酶活性在玉米胚乳发育中的作用。
Plant Physiol. 1982 Apr;69(4):988-9. doi: 10.1104/pp.69.4.988.
5
Purification and characterization of bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase from developing soybean seeds.发育中的大豆种子中双功能赖氨酸-酮戊二酸还原酶/酵母氨酸脱氢酶的纯化与特性分析
Plant Physiol. 2000 Jun;123(2):655-64. doi: 10.1104/pp.123.2.655.
6
Regulation of lysine catabolism through lysine-ketoglutarate reductase and saccharopine dehydrogenase in Arabidopsis.拟南芥中通过赖氨酸-酮戊二酸还原酶和酵母氨酸脱氢酶对赖氨酸分解代谢的调控
Plant Cell. 1997 Aug;9(8):1305-16. doi: 10.1105/tpc.9.8.1305.
7
Engineering of the aspartate family biosynthetic pathway in barley (Hordeum vulgare L.) by transformation with heterologous genes encoding feed-back-insensitive aspartate kinase and dihydrodipicolinate synthase.通过转化编码反馈不敏感天冬氨酸激酶和二氢吡啶二羧酸合酶的异源基因对大麦（Hordeum vulgare L.）中天冬氨酸家族生物合成途径进行工程改造。
Plant Mol Biol. 1996 Nov;32(4):611-20. doi: 10.1007/BF00020202.
8
Lysine synthesis and catabolism are coordinately regulated during tobacco seed development.在烟草种子发育过程中，赖氨酸的合成与分解代谢受到协同调控。
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2577-81. doi: 10.1073/pnas.91.7.2577.

本文引用的文献

1
Lysine Biosynthesis in Barley (Hordeum vulgare L.).大麦（Hordeum vulgare L.）中的赖氨酸生物合成。
Plant Physiol. 1974 Oct;54(4):638-43. doi: 10.1104/pp.54.4.638.
2
The location of nitrite reductase and other enzymes related to amino Acid biosynthesis in the plastids of root and leaves.亚硝酸盐还原酶及其他与氨基酸生物合成相关的酶在根和叶的质体中的位置。
Plant Physiol. 1974 Oct;54(4):550-5. doi: 10.1104/pp.54.4.550.
3
New intermediates in the catabolism of tryptophan in mammalian liver.哺乳动物肝脏中色氨酸分解代谢的新中间产物。
J Biol Chem. 1962 Jun;237:2043-5.
4
Enzymatic synthesis of L-pipecolic acid and L-proline.L-哌啶酸和L-脯氨酸的酶促合成
J Biol Chem. 1957 Dec;229(2):789-800.
5
Plant enzyme reactions leading to the formation of heterocyclic compounds. 1. The formation of unsaturated pyrrolidine and piperidine compounds.导致杂环化合物形成的植物酶反应。1. 不饱和吡咯烷和哌啶化合物的形成。
Biochem J. 1955 Sep;61(1):89-100. doi: 10.1042/bj0610089.
6
Studies of transamination.转氨基作用的研究。
Arch Biochem Biophys. 1954 Feb;48(2):395-401. doi: 10.1016/0003-9861(54)90355-0.
7
The conversion of lysine to pipecolic acid by Phaseolus vulgaris.菜豆将赖氨酸转化为哌啶酸的过程。
Arch Biochem Biophys. 1953 Nov;47(1):228-9. doi: 10.1016/0003-9861(53)90457-3.
8
Crystalline L-lysine oxygenase.结晶L-赖氨酸加氧酶。
J Biol Chem. 1966 Jun 10;241(11):2733-6.
9
Saccharopine, a product of lysine breakdown by mammalian liver.酵母氨酸，一种哺乳动物肝脏中赖氨酸分解的产物。
Biochem Biophys Res Commun. 1965 Jul 26;20(3):285-90. doi: 10.1016/0006-291x(65)90361-x.
10
Biosynthesis of the piperidine nucleus. The mode of incorporation of lysine into pipecolic acid and into piperidine alkaloids.哌啶环的生物合成。赖氨酸掺入哌可酸和哌啶生物碱的方式。
J Biol Chem. 1969 Jan 10;244(1):88-94.