Kumar R, Penniston J T
Department of Medicine, Mayo Clinic/Foundation, Rochester, Minn.
Contrib Nephrol. 1991;91:21-5. doi: 10.1159/000420153.
We examined the distribution of the plasma membrane calcium pump in several calcium-transporting tissues. Epitopes of the pump were found in the human kidney, specifically in the basolateral membrane of the distal tubule. The 28-kD calcium-binding protein co-localized with the calcium pump in cells of the distal tubule. Other human tissues that contain calcium pump epitopes include the basal surface of the syncytiotrophoblast of the placenta, human osteoblast-like cells and human choroid plexus. In the rat, calcium pump epitopes were found in the distal tubule of the kidney, the duodenum, the ileum, jejunum, placenta and in the choroid plexus. The pump is widely distributed in various calcium-transporting tissues and probably plays an important role in the translocation of calcium.
我们研究了质膜钙泵在几种钙转运组织中的分布情况。在人肾中发现了该泵的表位，具体位于远曲小管的基底外侧膜。28-kD钙结合蛋白与远曲小管细胞中的钙泵共定位。其他含有钙泵表位的人体组织包括胎盘合体滋养层的基底表面、人成骨样细胞和人脉络丛。在大鼠中，钙泵表位见于肾远曲小管、十二指肠、回肠、空肠、胎盘和脉络丛。该泵广泛分布于各种钙转运组织中，可能在钙的转运过程中起重要作用。
