衰老会降低大鼠大脑皮层中α1γ-氨基丁酸A型受体亚基的信使核糖核酸水平。
Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
作者信息
Mhatre M C, Fernandes G, Ticku M K
机构信息
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
出版信息
Eur J Pharmacol. 1991 Oct 14;208(2):171-4. doi: 10.1016/0922-4106(91)90068-s.
The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as alpha subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, alpha 1 mRNA level was markedly decreased (86% suppression). In contrast, alpha 1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.
研究了衰老对雄性Fischer F - 344大鼠大脑皮质中配体与γ-氨基丁酸（GABA）、苯二氮䓬和印防己毒素结合位点的结合以及GABAA受体α亚基mRNA水平的影响。在老年（730至770日龄）大鼠中，[35S]叔丁基双环磷硫代酸盐（TBPS）的结合显著减少。此外，α1 mRNA水平明显降低（抑制86%）。相比之下，小脑的α1 mRNA保持不变。这些发现表明大鼠大脑皮质中GABAA受体存在与年龄相关的选择性结构变化。
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