烯醚氨基酸，乙烯生物合成抑制剂，对氨酰-tRNA 合成酶和蛋白质合成的影响。
Influence of enol ether amino acids, inhibitors of ethylene biosynthesis, on aminoacyl transfer RNA synthetases and protein synthesis.
机构信息
United States Department of Agriculture, Science and Education Administration, Agricultural Research, AMRI; Post Harvest Plant Physiology Laboratory, Beltsville, Maryland 20705.
出版信息
Plant Physiol. 1979 Aug;64(2):289-92. doi: 10.1104/pp.64.2.289.
Abstract
The analogs of rhizobitoxine, aminoethoxyvinylglycine (AVG) (l-2-amino-4-2'-aminoethoxy-trans-3 butenoic acid) and methoxyvinylglycine (MVG) (l-2-amino-4-methoxy-trans-3-butenoic acid), that are potent inhibitors of ethylene biosynthesis at 0.1 millimolar also inhibited protein synthesis and charging of tRNA especially at 1 millimolar and higher concentrations. The saturated analog of MVG inhibited ethylene synthesis while the saturated analog of AVG did not. Both saturated AVG and MVG inhibit methionyl- and leucyl-amino acyl-tRNA synthetase. Because of the inhibition of amino acid metabolism in plant tissues by these rhizobitoxine analogs caution is advised in interpreting the results obtained with concentrations of compounds above 0.1 millimolar.
摘要
豆科植物根瘤菌素类似物、氨基乙氧基乙烯甘氨酸 (AVG)（l-2-氨基-4-2'-氨基乙氧基-trans-3 丁烯酸）和甲氧基乙烯甘氨酸 (MVG)（l-2-氨基-4-甲氧基-trans-3-丁烯酸）是乙烯生物合成的有效抑制剂，在 0.1 毫摩尔时也抑制蛋白质合成和 tRNA 的加载，尤其是在 1 毫摩尔及更高浓度时。MVG 的饱和类似物抑制乙烯合成，而 AVG 的饱和类似物则不抑制。饱和的 AVG 和 MVG 都抑制蛋氨酰和亮氨酰-氨基酰-tRNA 合成酶。由于这些根瘤菌素类似物抑制植物组织中的氨基酸代谢，因此在解释浓度高于 0.1 毫摩尔的化合物的结果时需要谨慎。
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