Bo P, Dallocchio C, Turrini R, Savoldi F
Istituto Neurologico, C. Mondino, Università di Pavia, Italy.
Boll Soc Ital Biol Sper. 1991 Jun;67(6):585-91.
The anticonvulsive efficacy of flumazenil, a specific antagonist of the ligands of the benzodiazepine receptor, was studied in the experimental seizures induced by electrical stimulation of corpus Amygdaloideum and Cornu Ammonis dorsale of the hippocampus in rabbits. In the amygdaloid seizure model flumazenil raised the threshold and/or reduced the afterdischarge duration. Results observed in the seizures induced by stimulation of hippocampus were less consistent. Possible explanations are discussed.
研究了氟马西尼（一种苯二氮䓬受体配体的特异性拮抗剂）对兔杏仁核和海马背侧角电刺激诱发的实验性癫痫发作的抗惊厥作用。在杏仁核癫痫模型中，氟马西尼提高了阈值和/或缩短了放电后持续时间。在海马刺激诱发的癫痫发作中观察到的结果不太一致。对可能的原因进行了讨论。
