Tuominen K, Korpi E R
Research Laboratories, Alko Ltd., Helsinki, Finland.
Pharmacol Biochem Behav. 1991 Oct;40(2):409-15. doi: 10.1016/0091-3057(91)90572-j.
During behavioral tests of alcohol sensitivity, rapid alcohol-opposing reactions may constitute an important mechanism in reducing the acute performance-impairing actions of alcohol. The alcohol-sensitive ANT (alcohol nontolerant) rats achieve lower plasma corticosterone concentrations after a tilting plane test of alcohol sensitivity (2 g ethanol/kg, IP) than the alcohol-insensitive AT (alcohol tolerant) rats, suggesting a dampening of activated stress mechanisms in the ANT rats. We have extended the comparison of these rat lines by examining central and peripheral stress responses to an acute 10-min swimming stress without ethanol administration. After the stress, plasma and adrenal corticosterone concentrations, adrenal dopamine concentrations, binding of [3H]Ro 5-4864 to adrenal membranes, and hypothalamic norepinephrine turnover were lower in the ANT than AT rats. Habituation to daily handling did not affect the stress effects or the differences between the rat lines. These results suggest that the alcohol-sensitive ANT rats have a diminished reaction to general stress, even in the absence of ethanol. This may impair their capacity to overcome the sedative and motor-impairing effects of moderate ethanol doses.
在酒精敏感性的行为测试中，快速的酒精对抗反应可能是减少酒精急性行为损害作用的重要机制。酒精敏感的ANT（酒精不耐受）大鼠在酒精敏感性倾斜平面测试（2 g乙醇/千克，腹腔注射）后，血浆皮质酮浓度低于酒精不敏感的AT（酒精耐受）大鼠，这表明ANT大鼠中激活的应激机制受到了抑制。我们通过检查在不给予乙醇的情况下，急性10分钟游泳应激引起的中枢和外周应激反应，扩展了对这些大鼠品系的比较。应激后，ANT大鼠的血浆和肾上腺皮质酮浓度、肾上腺多巴胺浓度、[3H]Ro 5-4864与肾上腺膜的结合以及下丘脑去甲肾上腺素周转率均低于AT大鼠。每日处理的习惯化并未影响应激效应或大鼠品系之间的差异。这些结果表明，即使在没有乙醇的情况下，酒精敏感的ANT大鼠对一般应激的反应也减弱。这可能会损害它们克服中等剂量乙醇的镇静和运动损害作用的能力。
