Mao F, Weng L L, Zheng H
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Yao Xue Xue Bao. 1991;26(8):611-4.
According to the character of structure and activity of the test reagents I-IV, two new reagents V and VI for detecting estrogen receptor of human mammary cancer cells were synthesized. This simplifies the route of synthesis and increases activity. Key intermediates VIII and IX were confirmed by IR, MS, UV and elemental analysis. The quantification of the final products V and VI were determined by UV. The result of preliminary clinico-pathological test shows compound V to be effective on estrogen receptor.
根据试剂I-IV的结构和活性特点，合成了两种检测人乳腺癌细胞雌激素受体的新试剂V和VI。这简化了合成路线并提高了活性。关键中间体VIII和IX通过红外光谱（IR）、质谱（MS）、紫外光谱（UV）和元素分析得以确认。最终产物V和VI的定量通过紫外光谱测定。初步临床病理测试结果表明化合物V对雌激素受体有效。
