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[灌注肺扫描在肺癌外科治疗中的临床价值]

[Clinical value of perfusion lung scanning in the surgical treatment of lung cancer].

作者信息

Wang J

出版信息

Zhonghua Yi Xue Za Zhi. 1991 Nov;71(11):620-2, 44.

PMID:1666974
Abstract

Perfusion lung scanning was performed in 49 patients with lung cancer. The relationships among the percent of tumor-bearing lung perfusion, invasion of the lung cancer, and operability of the tumor were studied. The results showed that the reduction in perfusion was related to involvement of the hilum (t = 4.1, P less than 0.001), and that when the relative perfusion of the tumor-bearing lung was less than one third (33%) of the total lung perfusion, the lung cancer was most likely inoperable (chi 2 = 13.9, P less than 0.0002). In this paper, predictive postoperative FEV1.0 calculated by combining the result of spirometry with quantitative measurement of lung perfusion was compared with actual postoperative FEV1.0 in 19 (19/49) patients. FEV1.0 after pneumonectomy was accurately predicted by the modified Neuhaus' equation (r = 0.929 3, P less than 0.001). Postlobectomy FEV1.0 could be predicted effectively by direct quantitative equation (r = 0.850 2, P less than 0.001), Our results showed that perfusion lung scanning is a very valuable method for preoperative examination of lung cancer. It may enable patients with unresectable lung cancer to save the trouble of exploratory thoracotomy and those with poor pulmonary function to seize the opportunity of surgical treatment.

摘要

对49例肺癌患者进行了肺灌注扫描。研究了荷瘤肺灌注百分比、肺癌侵犯情况与肿瘤可切除性之间的关系。结果显示,灌注减少与肺门受累有关(t = 4.1,P < 0.001),当荷瘤肺的相对灌注低于全肺灌注的三分之一(33%)时,肺癌最有可能无法切除(χ2 = 13.9,P < 0.0002)。本文将通过肺活量测定结果与肺灌注定量测量相结合计算出的预测术后第1秒用力呼气量(FEV1.0)与19例(19/49)患者的实际术后FEV1.0进行了比较。改良的Neuhaus方程能准确预测肺切除术后的FEV1.0(r = 0.929 3,P < 0.001)。直接定量方程能有效预测肺叶切除术后的FEV1.0(r = 0.850 2,P < 0.001)。我们的结果表明,肺灌注扫描是肺癌术前检查的一种非常有价值的方法。它可能使无法切除的肺癌患者免去开胸探查的麻烦,使肺功能差的患者抓住手术治疗的机会。

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