Angel Catherine E, George Elizabeth, Brooks Anna E S, Ostrovsky Lena L, Brown Tim La H, Dunbar P Rod
School of Biological Sciences, University of Auckland, 3a Symonds Street, Auckland, New Zealand.
J Immunol. 2006 May 15;176(10):5730-4. doi: 10.4049/jimmunol.176.10.5730.
Recent data from murine models have confirmed that Langerhans cells are not the only population of APCs in the skin involved in initiating immune responses. In healthy human skin, we identify CD1a(+) dermal APCs located close to the lymphatic vessels in the upper layers of the dermis that are unequivocally distinct from migrating Langerhans cells but exhibit both potent allostimulatory capacity and a chemotactic response to CCR7 ligands. In contrast, CD14(+) dermal APCs are distributed throughout the dermis and lack a chemotactic response to CCR7 ligands. CD1a(+) dermal APCs therefore represent an APC population distinct from Langerhans cells that are capable of migrating to lymph nodes and stimulating naive T cells. In humans, CD1a(+) dermal APCs may fulfill some of the roles previously ascribed to Langerhans cells.
来自小鼠模型的最新数据证实，朗格汉斯细胞并非皮肤中参与启动免疫反应的唯一抗原呈递细胞群体。在健康的人类皮肤中，我们发现位于真皮上层靠近淋巴管的CD1a(+)真皮抗原呈递细胞，它们与迁移的朗格汉斯细胞明显不同，但具有强大的同种异体刺激能力以及对CCR7配体的趋化反应。相比之下，CD14(+)真皮抗原呈递细胞分布于整个真皮，且对CCR7配体缺乏趋化反应。因此，CD1a(+)真皮抗原呈递细胞代表了一种不同于朗格汉斯细胞的抗原呈递细胞群体，它们能够迁移至淋巴结并刺激初始T细胞。在人类中，CD1a(+)真皮抗原呈递细胞可能发挥一些先前归因于朗格汉斯细胞的作用。
