Brouzas Dimitrios, Droutsas Dimitrios, Charakidas Antonios, Malias Ioannis, Georgiadou Efstratia, Apostolopoulos Michael, Moschos Michael
Department of Ophthalmology, University of Athens, Athens, Greece.
Cornea. 2006 May;25(4):470-1. doi: 10.1097/01.ico.0000183488.78012.33.
To report a case of corneal endothelial decompensation and iris pigment dispersion following the inadvertent use of methylene blue 1% for capsular staining during cataract surgery.
Case report.
During an otherwise routine phacoemulsification cataract surgery, inadvertent anterior capsule staining with methylene blue 1% instead of trypan blue 0.025% was performed. Copious irrigation of the anterior chamber with balanced salt solution was initiated upon identification of the wrong dye. The operation was completed with minimal ultrasound energy without complications.
Iris discoloration and severe corneal edema developed in the early postoperative period, resulting in severe visual loss. The patient developed bullous keratopathy and underwent penetrating keratoplasty 16 months later.
In vivo intracameral injection of methylene blue 1% induces extreme cytotoxicity, primarily on the corneal endothelium and iris epithelium.
报告1例白内障手术期间意外使用1%亚甲蓝进行囊膜染色后发生角膜内皮失代偿和虹膜色素播散的病例。
病例报告。
在一次常规的超声乳化白内障手术中，意外使用1%亚甲蓝而非0.025%台盼蓝对前囊膜进行了染色。在发现染料错误后，立即用平衡盐溶液对前房进行大量冲洗。手术以最小的超声能量完成，无并发症发生。
术后早期出现虹膜变色和严重角膜水肿，导致严重视力丧失。患者发生大泡性角膜病变，并于16个月后接受了穿透性角膜移植术。
眼内前房注射1%亚甲蓝会引发极强的细胞毒性，主要作用于角膜内皮和虹膜上皮。
