Raat Hein, Mohangoo Ashna D, Grootenhuis Martha A
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):180-5. doi: 10.1097/01.all.0000225157.67897.c2.
This review summarizes recent studies on the feasibility, reliability and validity of pediatric health-related quality of life questionnaires and gives an overview of recent applications of these measures in pediatrics.
The often-applied short form of the Child Health Questionnaire (CHQ-PF28) provides reliable physical and psychosocial summary measures, but reliable estimates for each scale require the longer version (CHQ-PF50). In addition to this questionnaire, the Pediatric Quality of Life Inventory is another reliable and valid measure. The TNO-AZL Preschool Children Quality of Life questionnaire is a feasible and reliable measure for preschool children. Generally, generic questionnaires are less sensitive to the impact of specific diseases than are disease-specific questionnaires. Parent and self-reports provide different outlooks on quality of life, which complement each other.
There are several feasible, reliable and validated pediatric quality of life questionnaires that can be used in clinical trials. These include generic and disease-specific questionnaires and health profile measures, as well as preference-based measures in pediatric settings. Generally, a combination of these types of questionnaires would be the most appropriate approach. Moreover, a combination of parent and self-reports should be applied. Appropriate selection of outcome measures will enhance the quality of pediatric studies and the ability to assess treatment effects in clinical trials.
本综述总结了近期关于儿童健康相关生活质量问卷的可行性、可靠性和有效性的研究，并概述了这些测量方法在儿科领域的最新应用。
常用的儿童健康问卷简表（CHQ-PF28）提供了可靠的身体和心理社会综合测量指标，但每个量表的可靠估计需要更长版本（CHQ-PF50）。除了该问卷外，儿童生活质量量表也是另一种可靠且有效的测量方法。TNO-AZL学龄前儿童生活质量问卷是一种适用于学龄前儿童的可行且可靠的测量方法。一般来说，通用问卷对特定疾病影响的敏感性低于疾病特异性问卷。家长报告和自我报告对生活质量提供了不同的视角，二者相互补充。
有几种可行、可靠且经过验证的儿童生活质量问卷可用于临床试验。这些问卷包括通用问卷、疾病特异性问卷和健康状况测量指标，以及儿科环境中的基于偏好的测量方法。一般来说，结合使用这些类型的问卷将是最合适的方法。此外，应同时采用家长报告和自我报告。适当选择结局测量指标将提高儿科研究的质量以及评估临床试验中治疗效果的能力。
