Bali Maria Antonietta, Golstein Philippe, Devière Jacques, Chatterjee Nirjhar, Matos Celso
Department of Radiology, MR Unit, Erasme Hospital, ULB, Brussels, Belgium.
Pancreas. 2006 May;32(4):346-50. doi: 10.1097/01.mpa.0000220858.93496.a8.
Somatostatin inhibitory effect on the exocrine pancreas has been demonstrated by clinical and experimental studies performed with invasive investigative methods. The aim of this study was to quantify the inhibitory effect of low doses of somatostatin (62.5, 125, and 250 microg) on secretin-stimulated pancreatic exocrine secretions using magnetic resonance cholangiopancreatography (MRCP).
Ten healthy volunteers underwent 4 MRCP at a 1-week interval. At each MRCP, 1 of the 3 doses of Somatostatin or the placebo was given by the intravenous route for a period of 40 minutes. After 20 minutes from the beginning of drug infusion, secretin was injected (0.3 CU/kg). MRCP was performed before and every 30 to 45 seconds for 15 minutes after secretin administration. Pancreatic exocrine secretions were quantified by the measurements of pancreatic flow output and total excreted volume, derived from a linear regression between MRCP calculated volumes and time.
For the 3 doses of somatostatin, pancreatic flow output was significantly reduced compared to placebo (P < 0.05). Total excreted volume was significantly reduced only for the doses of 62.5 and 250 microg. No statistical significant differences were observed among the 3 doses.
Low doses of somatostatin inhibit pancreatic exocrine secretions as demonstrated noninvasively with MRCP.
采用侵入性研究方法进行的临床和实验研究已证实生长抑素对外分泌胰腺具有抑制作用。本研究的目的是使用磁共振胰胆管造影（MRCP）定量低剂量生长抑素（62.5、125和250微克）对促胰液素刺激的胰腺外分泌的抑制作用。
10名健康志愿者每隔1周接受4次MRCP检查。在每次MRCP检查时，通过静脉途径给予3种剂量的生长抑素或安慰剂中的1种，持续40分钟。在药物输注开始20分钟后，注射促胰液素（0.3 CU/kg）。在给予促胰液素之前以及给药后每30至45秒进行15分钟的MRCP检查。通过测量胰腺流量输出和总排泄量来定量胰腺外分泌，这些数据来自MRCP计算体积与时间之间的线性回归。
与安慰剂相比，3种剂量的生长抑素均使胰腺流量输出显著降低（P < 0.05）。仅62.5微克和250微克剂量的总排泄量显著降低。3种剂量之间未观察到统计学上的显著差异。
低剂量生长抑素抑制胰腺外分泌，这通过MRCP非侵入性地得到证实。
