Morgan B, Utting J F, Higginson A, Thomas A L, Steward W P, Horsfield M A
Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK.
Br J Cancer. 2006 May 22;94(10):1420-7. doi: 10.1038/sj.bjc.6603140.
Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respiratory motion. Data from phantom studies and a reproducibility study in solid human tumours are presented. The reproducibility study showed a coefficient of variation (CoV) of 19.1% for K(trans) and 15.8% for the initial area under the contrast enhancement curve (IAUC). This was improved to 16 and 13.9% if tumours of diameter less than 3 cm were excluded. The individual repeatability (the range within which individual measurements are expected to fall) was 30.6% for K(trans) and 26.5% for IAUC for tumours greater than 3 cm diameter. This approach to DCE-MRI image acquisition can be performed with standard clinical scanners, and data analysis is straightforward. For treatment trials with 10 patients in a cohort, the CoV implies that the method would be sensitive to a treatment effect of greater than 18%. The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE-MRI technique.
动态对比增强磁共振成像（DCE-MRI）可作为癌症治疗成功的生物标志物。简单、可重复的技术可能会扩大其应用范围。本文展示了一种单层成像技术。图像采集在不到500毫秒内完成，使其对呼吸运动相对不敏感。文中给出了体模研究和实体人类肿瘤重复性研究的数据。重复性研究表明，Ktrans的变异系数（CoV）为19.1%，对比增强曲线下初始面积（IAUC）的变异系数为15.8%。如果排除直径小于3厘米的肿瘤，这一数值分别提高到16%和13.9%。对于直径大于3厘米的肿瘤，Ktrans的个体重复性（预期个体测量值所在范围）为30.6%，IAUC为26.5%。这种DCE-MRI图像采集方法可通过标准临床扫描仪进行，数据分析也很简单。对于每组有10名患者的治疗试验，CoV表明该方法对大于18%的治疗效果敏感。个体重复性完全在使用这种DCE-MRI技术的临床研究中显示为重要的40%变化范围内。
