Barnes Peter J
National Heart and Lung Institute, Imperial College, London, United Kingdom.
J Clin Invest. 2006 May;116(5):1210-2. doi: 10.1172/JCI28535.
Most G protein-coupled receptors (GPCRs) probably exist as homodimers, but it is increasingly recognized that GPCRs may also dimerize with other types of GPCRs and that this physical interaction may affect the function of either receptor. A study in this issue of the JCI demonstrates how heterodimerization between prostaglandin E receptors and beta(2)-adrenergic receptors (beta(2)ARs) in airway smooth muscle cells results in uncoupling of beta(2)ARs and a diminished bronchodilator response to beta(2)AR agonists (see the related article beginning on page 1400). This illustrates what we believe to be a novel mechanism of receptor cross-talk and highlights the potential importance of GPCR heterodimerization in diseases such as asthma and how this could lead to the development of more specific therapies in the future.
大多数G蛋白偶联受体（GPCR）可能以同二聚体形式存在，但人们越来越认识到，GPCR也可能与其他类型的GPCR形成二聚体，并且这种物理相互作用可能会影响任一受体的功能。本期《临床研究杂志》上的一项研究表明，气道平滑肌细胞中前列腺素E受体与β2-肾上腺素能受体（β2AR）之间的异二聚化如何导致β2AR解偶联，并减弱对β2AR激动剂的支气管扩张反应（见第1400页开始的相关文章）。这说明了我们认为是一种新型的受体相互作用机制，并突出了GPCR异二聚化在诸如哮喘等疾病中的潜在重要性，以及这在未来如何能够导致开发出更具特异性的疗法。
