Frank Philippe G, Lisanti Michael P
Department of Urology and the Albert Einstein Diabetes Research and Training Center (DRTC), Albert Einstein College of Medicine, New York, New York, USA.
J Clin Invest. 2006 May;116(5):1222-5. doi: 10.1172/JCI28509.
In blood vessels, endothelia are submitted to constant shear effects and are, under normal conditions, capable of responding to any variation in hemodynamic forces. Caveolae - 50- to 100-nm plasma membrane invaginations present at the surface of terminally differentiated cells and particularly enriched in ECs - are composed of a high sphingolipid and cholesterol content and the protein caveolin-1 (Cav-1). Previous studies have suggested that caveolae and endothelial Cav-1 may regulate the vascular response to altered shear stress. In this issue of the JCI, Yu et al. have examined the role of Cav-1/caveolae in the regulation of flow-induced alterations (i.e., mechanotransduction) in vessels from wild-type mice, Cav-1-deficient mice, and Cav-1-deficient mice re-expressing Cav-1 only in ECs. Their data suggest that caveolae/Cav-1 may act as sensors of altered shear stress and that they also organize the signaling response in stimulated ECs (see the related article beginning on page 1284).
在血管中，内皮细胞受到持续的剪切力作用，并且在正常情况下，能够对血流动力学力的任何变化做出反应。小窝——存在于终末分化细胞表面、特别是在内皮细胞中高度富集的50至100纳米的质膜内陷结构——由高含量的鞘脂、胆固醇以及小窝蛋白-1（Cav-1）组成。先前的研究表明，小窝和内皮细胞中的Cav-1可能调节血管对剪切应力改变的反应。在本期《临床研究杂志》中，Yu等人研究了Cav-1/小窝在野生型小鼠、Cav-1缺陷小鼠以及仅在内皮细胞中重新表达Cav-1的Cav-1缺陷小鼠血管中流动诱导变化（即机械转导）调节中的作用。他们的数据表明，小窝/Cav-1可能作为剪切应力改变的传感器，并且它们还在受刺激的内皮细胞中组织信号反应（见第1284页开始的相关文章）。
