Li C S
Neurosurgical Service, Kuang Tien General Hospital, Taiwan.
Acta Neurochir (Wien). 2006 Jul;148(7):795-9; discussion 799. doi: 10.1007/s00701-006-0776-7. Epub 2006 May 4.
A radiation dose lower than what had previously been recommended was given to a case of intrasellar germinoma in a 17-year-old patient who suffered from migraine-like headache for 2 years, amenorrhoea for 3 months and a body-weight loss of 10 kg over 4 months. Baseline assessment of pituitary hormone reserve was within the lower limits of the normal range, except for an elevated serum prolactin level (PRL). Magnetic resonance imaging (MRI) showed an abnormal, slightly enhanced mass in the pituitary fossa, extending along the pituitary stalk and to the hypothalamus. Transsphenoidal removal of the intrasellar part of the tumour was performed and microscopic sections of the surgical specimens revealed a pure germinoma. Adjunctive radiation therapy (RT) was given 3 weeks after surgery. A total dose of only 27 Gy was delivered to this patient. The patient's menstrual cycles resumed in 4 months. Repeated MRI follow-up showed no recurrence of the tumour.
一名17岁的鞍内生殖细胞瘤患者接受了低于先前推荐剂量的放射治疗。该患者有2年偏头痛样头痛病史，闭经3个月，4个月内体重减轻10kg。垂体激素储备的基线评估在正常范围的下限，血清催乳素水平（PRL）升高除外。磁共振成像（MRI）显示垂体窝内有异常的、轻度强化的肿块，沿垂体柄延伸至下丘脑。经蝶窦切除肿瘤的鞍内部分，手术标本的显微镜切片显示为纯生殖细胞瘤。术后3周给予辅助放射治疗（RT）。该患者总共仅接受了27Gy的剂量。患者在4个月后月经周期恢复。MRI复查显示肿瘤无复发。
