Solban Nicolas, Rizvi Imran, Hasan Tayyaba
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Lasers Surg Med. 2006 Jun;38(5):522-31. doi: 10.1002/lsm.20345.
Photodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non-neoplastic pathologies.
STUDY DESIGN/MATERIALS AND METHODS: PDT usually occurs when reactive oxygen species (ROS) generated from light-activated chemicals (photosensitizer, PS) destroy the target. For non-dermatologic applications the PS are delivered systemically and accumulate, at different concentrations, in most organs.
Typically there is a modest enhanced accumulation of the PS in tumor tissues, providing a first level of selectivity. Additional selectivity is provided by the confined illumination of the target area with the appropriate wavelength of light. For the treatment of pathologies in complex anatomical sites, such as in the peritoneal cavity, where restricted illumination is difficult; improved targeting of the PS is necessary to prevent damage to the surrounding healthy tissue. This article will focus on targeted PDT.
光动力疗法（PDT）是一种用于治疗各种肿瘤性和非肿瘤性疾病的新兴治疗方式。
研究设计/材料与方法：当光激活化学物质（光敏剂，PS）产生的活性氧（ROS）破坏靶标时，通常会发生光动力疗法。对于非皮肤科应用，光敏剂通过全身给药，并以不同浓度在大多数器官中蓄积。
通常，肿瘤组织中光敏剂的蓄积会适度增强，这提供了第一层选择性。通过用适当波长的光对靶区域进行受限照射可提供额外的选择性。对于治疗复杂解剖部位的疾病，如在腹腔中，由于难以进行受限照射，因此需要改进光敏剂的靶向性以防止对周围健康组织造成损伤。本文将重点关注靶向光动力疗法。
