Popkov V L, Fil'chukova I A, Lapina N V, Galenko-Yaroshevskii V P, Dukhanin A S
Krasnodar Branch, Southern Bureau, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2005 Oct;140(4):391-3. doi: 10.1007/s10517-005-0499-4.
Parameters of NO metabolism in the gingiva were studied during experimental periodontitis accompanied by alloxan diabetes and exogenous hypercholesterolemia. We measured activities of inducible and constitutive NO synthase and concentrations of stable NO end metabolites in rat gingival tissue (total contents of nitrite and nitrate). Under pathological conditions NO-metabolism significantly differed from the control. Treatment with mexidol for 14 days significantly decreased activity of inducible NO synthase in the gingiva of experimental animals.
在伴有四氧嘧啶糖尿病和外源性高胆固醇血症的实验性牙周炎期间，研究了牙龈中一氧化氮（NO）代谢的参数。我们测量了大鼠牙龈组织中诱导型和组成型NO合酶的活性以及稳定的NO终末代谢产物的浓度（亚硝酸盐和硝酸盐的总含量）。在病理条件下，NO代谢与对照组有显著差异。用美西律治疗14天可显著降低实验动物牙龈中诱导型NO合酶的活性。
