Zhanaeva S Y, Korolenko T A, Nekrasov B G, Nikolin V P, Kaledin V I
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Bull Exp Biol Med. 2005 Oct;140(4):449-51. doi: 10.1007/s10517-005-0516-7.
Stimulation of mouse tissue macrophages with carboxymethylated beta-(1-->43)-D-glycan 1 day before intravenous injection of tumor cells increased the number and weight of implants (experimental metastases) of mouse hepatocarcinoma and adenocarcinoma in the liver and lungs, respectively. Suppression of liver macrophages with gadolinium chloride or sequestration of cells during intraperitoneal administration of macrophage attractants inhibited metastatic dissemination of hepatocarcinoma and adenocarcinoma in the liver and lungs, respectively. In the latter case animal lifespan increased. Our results indicate that at certain stages of metastatic dissemination, activation of mononuclear phagocytes can stimulate the formation and growth of metastases.
在静脉注射肿瘤细胞前1天，用羧甲基化的β-(1→43)-D-聚糖刺激小鼠组织巨噬细胞，可分别增加小鼠肝癌和腺癌在肝脏和肺中的种植瘤（实验性转移灶）数量及重量。用氯化钆抑制肝脏巨噬细胞或在腹腔注射巨噬细胞趋化剂期间隔离细胞，可分别抑制肝癌和腺癌在肝脏和肺中的转移扩散。在后一种情况下，动物寿命延长。我们的结果表明，在转移扩散的某些阶段，单核吞噬细胞的激活可刺激转移灶的形成和生长。
