使用镊子型金属受体的形状选择性荧光传感体系。

Shape-selective fluorescent sensing ensemble using a tweezer-type metalloreceptor.

作者信息

Plante Jeffrey P, Glass Timothy E

机构信息

Department of Chemistry, University of Missouri-Columbia, 65211, USA.

出版信息

Org Lett. 2006 May 11;8(10):2163-6. doi: 10.1021/ol060641k.

DOI:10.1021/ol060641k

PMID:16671807

Abstract

[reaction: see text] A fluorescent sensing ensemble for pyridine-derived compounds is described. The receptor portion of the ensemble is prepared from a bisimidazole pyridine which coordinates copper to form a well-defined cavity. Small heteroaromatic guests such as adenine bind strongly in the cavity. The fluorescent response is provided by a dye which is coordinated to the receptor and quenched by the metal ion. The dye is released upon guest binding providing up to 25-fold fluorescence increases.

摘要

[反应：见正文] 描述了一种用于吡啶衍生化合物的荧光传感体系。该体系的受体部分由双咪唑吡啶制备而成，其与铜配位形成一个明确的空腔。诸如腺嘌呤之类的小杂环芳烃客体在该空腔中强烈结合。荧光响应由一种与受体配位并被金属离子淬灭的染料提供。客体结合时染料被释放，荧光增强可达25倍。