前列腺素 - A2的化学转化：一系列新型的C - 10卤代、C - 12羟基化前列腺素 - A2类似物。
Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues.
作者信息
Ratnayake Anokha S, Bugni Tim S, Veltri Charles A, Skalicky Jack J, Ireland Chris M
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City, 84112, USA.
出版信息
Org Lett. 2006 May 11;8(10):2171-4. doi: 10.1021/ol0606583.
Abstract
[reaction: see text] Synthesis of a novel class of C-10 halogenated and C-12 oxygenated prostaglandin-A(2) derivatives (6a-6c) has been accomplished. (15S)-Prostaglandin-A(2) (1), from the gorgonian Plexaura homomalla, served as the starting material for the synthesis. The absolute configuration was determined using NMR.
摘要
[反应：见正文] 已完成一类新型的C-10卤代和C-12氧化前列腺素-A₂衍生物（6a - 6c）的合成。来自柳珊瑚Plexaura homomalla的（15S）-前列腺素-A₂（1）用作合成的起始原料。通过核磁共振确定了绝对构型。
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