贫血治疗患者满意度问卷（PSQ-An）的验证
Validation of a patient satisfaction questionnaire for anemia treatment, the PSQ-An.
作者信息
Nordyke Robert J, Chang Chih-Hung, Chiou Chiun-Fang, Wallace Joel F, Yao Bin, Schwartzberg Lee S
机构信息
Cerner Health Insights, 9100 Wilshire Blvd, Ste, 655E, Beverly Hills, CA 90290, USA.
出版信息
Health Qual Life Outcomes. 2006 May 3;4:28. doi: 10.1186/1477-7525-4-28.
BACKGROUND
Treating anemia associated with chemotherapy and many cancers is often necessary. However, patient satisfaction with anemia treatment is limited by the lack of validated instruments. We developed and validated a new treatment-specific patient satisfaction instrument: the Patient Satisfaction Questionnaire for Anemia Treatment (PSQ-An). Treatment burden and overall satisfaction scales were designed for ease of use in clinical practice.
METHODS
312 cancer patients (141 breast, 69 gynecological, and 102 non-small cell lung) were targeted to complete the PSQ-An at 4 week intervals. Data from weeks 5 and 9 were analyzed. Patients also completed the MOS SF-36 Global Health assessment and questions concerning resources devoted to anemia treatment. Item reduction used endorsement rates, floor/ceiling effects, and item-item correlations. Factor analysis identified meaningful subscales. Test-retest reliability was assessed. Construct validity was tested, using Pearson's correlations, by comparing subscale scores to Global Health, hemoglobin levels, and resources devoted to anemia treatment.
RESULTS
The overall response rate was 92.9% (264/284) at week 5. Most (84.2%) of the patients were female, and the mean (SD) age was 60.2 (+/- 11.8) years. Two distinct subscales were identified measuring treatment burden (7 items) and overall satisfaction (2 items). Test-retest reliability was examined (ICC: 0.45-0.67); both were internally consistent (alpha = 0.83). Both subscales exhibited convergent and divergent validity with independent measures of health. ANOVA results indicated that the PSQ-An Satisfaction subscale discriminated between 5 levels of MOS SF-36 Global Health (P = 0.006).
CONCLUSION
The PSQ-An is a validated, treatment-specific instrument for measuring satisfaction with anemia treatment for cancer patients. PSQ-An subscales reflect the burden of injection anemia treatment on cancer patients and their assessment of the overall treatment value.
背景
治疗与化疗及多种癌症相关的贫血往往是必要的。然而，由于缺乏经过验证的工具，患者对贫血治疗的满意度有限。我们开发并验证了一种新的针对特定治疗的患者满意度工具：贫血治疗患者满意度问卷（PSQ-An）。治疗负担和总体满意度量表的设计便于在临床实践中使用。
方法
312名癌症患者（141名乳腺癌患者、69名妇科癌症患者和102名非小细胞肺癌患者）被要求每隔4周完成一次PSQ-An。分析了第5周和第9周的数据。患者还完成了MOS SF-36全球健康评估以及有关用于贫血治疗的资源的问题。项目缩减采用认可率、地板/天花板效应和项目间相关性。因子分析确定了有意义的子量表。评估了重测信度。通过将子量表得分与全球健康、血红蛋白水平以及用于贫血治疗的资源进行比较，使用Pearson相关性检验了结构效度。
结果
第5周时总体应答率为92.9%（264/284）。大多数患者（84.2%）为女性，平均（标准差）年龄为60.2（±11.8）岁。确定了两个不同的子量表，分别测量治疗负担（7个项目）和总体满意度（2个项目）。检验了重测信度（组内相关系数：0.45 - 0.67）；两者在内部都是一致的（α = 0.83）。两个子量表在与独立健康指标的比较中均表现出收敛效度和区分效度。方差分析结果表明，PSQ-An满意度子量表能够区分MOS SF-36全球健康的5个水平（P = 0.006）。
结论
PSQ-An是一种经过验证的、针对特定治疗的工具，用于测量癌症患者对贫血治疗的满意度。PSQ-An子量表反映了癌症患者注射性贫血治疗的负担及其对总体治疗价值的评估。
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