McGuinness N, Anwyl R, Rowan M
Department of Physiology, Trinity College, Dublin, Ireland.
Neuroreport. 1991 Nov;2(11):688-90. doi: 10.1097/00001756-199111000-00014.
Trans-ACPD, a metabotropic glutamate receptor agonist, enhanced both the short-term potentiation (STP) at 1 and 5 min, and long-term potentiation (LTP) at 20 min, following tetanic stimulation, of the population, excitatory postsynaptic potential (epsp) recorded from CA1 of the rat hippocampal slice. The enhancement of both STP and LTP also occurred in the presence of the protein kinase inhibitor sphingosine, indicating that the enhancement is most likely to occur through the inositol phosphate rather than the protein kinase limb following receptor activation and phosphoinositide hydrolysis. LTP of the low frequency population epsp was not induced by t-ACPD, even at 100 microM. The metabotropic glutamate receptor may have an important role in LTP induction or modulation.
反式-ACPD是一种代谢型谷氨酸受体激动剂，在强直刺激后，它增强了大鼠海马切片CA1区记录到的群体兴奋性突触后电位（epsp）在1分钟和5分钟时的短期增强（STP）以及在20分钟时的长期增强（LTP）。在存在蛋白激酶抑制剂鞘氨醇的情况下，STP和LTP的增强也会发生，这表明这种增强很可能是通过受体激活和磷酸肌醇水解后的肌醇磷酸途径而非蛋白激酶途径发生的。即使在100微摩尔浓度下，反式-ACPD也不能诱导低频群体epsp的LTP。代谢型谷氨酸受体可能在LTP的诱导或调节中起重要作用。
