Sell Manfred, Huber-Schumacher Sabine, van Landeghem Frank K H
Institute of Pathology, Vivantes Klinikum Neukölln, Rudower Strasse 48, 12351 Berlin, Germany.
Childs Nerv Syst. 2006 Jul;22(7):729-33. doi: 10.1007/s00381-006-0049-z. Epub 2006 May 4.
A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory insufficiency.
Autopsy disclosed a large well-delimited tumor with a sponge-like appearance due to high vascularization, which involved nearly the whole left cerebral hemisphere and led to marked hydrocephalus by secondary aqueductal stenosis. Histological and immunohistochemical examination confirmed the diagnosis of a malignant glioma with features of a glioblastoma multiforme (GBM) matching well with previous findings in primary pediatric GBMs.
The present case demonstrates that malignant congenital neoplasms should be considered in the differential diagnosis of fetal intracranial hemorrhage.
报道了一例罕见的先天性脑肿瘤，在一名孕32周男性胎儿中，产前超声检查提示肿瘤内有大量出血。患儿出生后不久因心肺功能不全死亡。
尸检发现一个边界清楚的大肿瘤，由于血管高度丰富呈海绵状外观，几乎累及整个左脑半球，并因继发性导水管狭窄导致明显脑积水。组织学和免疫组化检查确诊为恶性胶质瘤，具有多形性胶质母细胞瘤（GBM）的特征，与原发性儿童GBM的既往研究结果相符。
本病例表明，在胎儿颅内出血的鉴别诊断中应考虑恶性先天性肿瘤。
