Akkerman Jan Willm N
Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Semin Thromb Hemost. 2006 Apr;32(3):295-304. doi: 10.1055/s-2006-939442.
In hematopoietic stem cells and megakaryocytes, the thrombopoietin (TPO) receptor signals to control proliferation, maturation, and antiapoptosis. In the anucleated platelet, much of this signaling appears out of place. Nevertheless, platelets possess TPO receptors and the cascades for transduction of TPO signals, but the final effect has shifted from DNA regulation to control of platelet aggregation and secretion. Although at physiological concentrations, TPO is not a sufficiently strong stimulator to trigger platelet functions in the absence of a second stimulator, TPO increases the sensitivity of platelets to agonist stimulation, leading to better functions at lower stimulation.
在造血干细胞和巨核细胞中，血小板生成素（TPO）受体发出信号以控制细胞增殖、成熟和抗凋亡。在无核血小板中，许多这种信号传导似乎并不合适。然而，血小板拥有TPO受体以及TPO信号转导的级联反应，但最终效应已从DNA调控转变为对血小板聚集和分泌的控制。尽管在生理浓度下，TPO在没有第二种刺激物的情况下并不是触发血小板功能的足够强的刺激物，但TPO会增加血小板对激动剂刺激的敏感性，从而在较低刺激下实现更好的功能。
