Effects of intraventricular injections of N-6,O-2-Dibutyryl adenosine 3,5-monophosphate on the rat brain cholinergic system.

Intraventricular injections of dibutyryl cyclic AMP effected increases of acetylcholine in the cerebral cortex-striatal and subcortical regions. No increase in choline acetyltransferase activity was observed; however, there was a significant decrease in acetylcholinesterase activity in the subcortical region.