Greene R M, Linask K K, Pisano M M, Weston W M, Lloyd M R
Department of Anatomy, School of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
J Craniofac Genet Dev Biol. 1991 Oct-Dec;11(4):262-76.
Investigations of the pathogenesis of cleft palate have been hampered by the complexity of normal craniofacial ontogenesis and by an incomplete understanding of mechanisms involved in normal palate development. This article deals with cellular aspects of the developing craniofacial region and discusses the facts and problems in the field as they relate to the normal development of the secondary palate, with emphasis on the regulation of hormone- and growth factor-induced transmembrane signalling and intracellular signal transduction.
正常颅面发生过程的复杂性以及对正常腭部发育所涉及机制的不完全理解，阻碍了腭裂发病机制的研究。本文探讨了发育中颅面区域的细胞层面问题，并讨论了该领域与继发腭正常发育相关的事实和问题，重点在于激素和生长因子诱导的跨膜信号传导及细胞内信号转导的调控。
