Huang J, DeLano M, Cao Y
Department of Radiology, Michigan State University, East Lansing, MI 48824, USA.
Cephalalgia. 2006 May;26(5):554-60. doi: 10.1111/j.1468-2982.2006.01067.x.
A robust, visual masking test that was developed to be feasible with functional magnetic resonance imaging (fMRI) was used to examine the visual cortical inhibitory function in migraine patients with visual aura at both psychophysical and cortical levels. The study showed that the decreased visibility of a visual target was associated with a reduction in cortical activation in the primary visual cortex. The suppression of the transient on-response and after-discharge of neurons to the target was most likely to be responsible for reducing cortical activation, rendering the target less visible or invisible. The migraine patients were equally susceptible to visual masking and showed no difference in cortical activation when compared with age- and sex-matched non-headache controls, demonstrating that visual cortical inhibitory function was not impaired under the experimental conditions. Although these results are not in conflict with the general cortical hyperexcitability theory in migraine, they provide evidence to show the limitation to the theory.
一种专为功能磁共振成像（fMRI）设计的、可行的强大视觉掩蔽测试，被用于在心理物理学和皮层水平上检查有视觉先兆的偏头痛患者的视觉皮层抑制功能。研究表明，视觉目标可见度的降低与初级视觉皮层中皮层激活的减少有关。神经元对目标的瞬态起始反应和后放电的抑制最有可能是皮层激活减少的原因，使目标变得不那么可见或不可见。偏头痛患者对视觉掩蔽同样敏感，与年龄和性别匹配的无头痛对照组相比，皮层激活没有差异，这表明在实验条件下视觉皮层抑制功能没有受损。尽管这些结果与偏头痛的一般皮层兴奋性过高理论并不冲突，但它们提供了证据表明该理论存在局限性。
