Roche N, Schnitzler A, Genêt F, Ben Smail D
Service de médecine physique et réadaptation, hôpital Raymond-Poincaré, APHP, faculté de médecine Paris Ile-de-France Ouest, université de Versailles-Saint-Quentin, 104, boulevard R.-Poincaré, 92380 Garches, France.
Ann Readapt Med Phys. 2006 Jun;49(5):248-51. doi: 10.1016/j.annrmp.2006.03.003. Epub 2006 Mar 31.
Intrathecally delivered baclofen has been used as a treatment for severe spasticity since 1984. After a successful intrathecal baclofen trial, a programmable drug delivery system was implanted. Few early complications such as infection or hematoma are observed after this surgery.
To describe an unusual and unknown complication of intrathecal baclofen therapy.
We report 2 cases of complications of intrathecal baclofen therapy, radiculalgy, that appeared early after pump implantation. The clinical symptoms and computed tomography (CT) results are described.
The first patient described pain, which evoked left S1 radiculopathic features. The second had left L5 radiculopathic involvement. The mean pain level was estimated on a 10-point visual analog scale as 7.5 (range 4-9). Lumbar CT scan showed a conflict between the symptomatic root and the catheter and eliminated other causes of the symptoms. Treatment with analgesic drugs was successful in 1 patient. The other presented with proximal disconnection of the catheter, which led to surgical replacement of the catheter. The pain disappeared after this surgery.
Intrathecal baclofen therapy with a subcutaneously implanted progammable pump can be complicated by radiculalgy secondary to a conflict between the catheter and symptomatic root. The diagnosis is made by CT lumbar scan. If medical treatment is not sufficient, surgery could be proposed to replace the catheter.
自1984年以来,鞘内注射巴氯芬一直被用作治疗严重痉挛的方法。在鞘内注射巴氯芬试验成功后,植入了一个可编程药物输送系统。该手术后很少观察到早期并发症,如感染或血肿。
描述鞘内注射巴氯芬治疗一种罕见且未知的并发症。
我们报告2例鞘内注射巴氯芬治疗的并发症——神经根痛,这是在泵植入后早期出现的。描述了临床症状和计算机断层扫描(CT)结果。
首例患者描述有疼痛,引发左侧S1神经根病特征。第二例有左侧L5神经根受累。平均疼痛程度用10分视觉模拟量表评估为7.5分(范围4 - 9分)。腰椎CT扫描显示有症状的神经根与导管之间存在冲突,并排除了其他症状原因。1例患者使用镇痛药治疗成功。另1例出现导管近端断开,导致进行了导管手术更换。该手术后疼痛消失。
皮下植入可编程泵的鞘内注射巴氯芬治疗可能因导管与有症状神经根之间的冲突而并发神经根痛。通过腰椎CT扫描进行诊断。如果药物治疗不足,可以建议进行手术更换导管。