突触前去沉默：探寻一种机制。

Presynaptic unsilencing: searching for a mechanism.

作者信息

Atasoy Deniz, Kavalali Ege T

机构信息

Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

出版信息

Neuron. 2006 May 4;50(3):345-6. doi: 10.1016/j.neuron.2006.04.018.

DOI:10.1016/j.neuron.2006.04.018

PMID:16675387

Abstract

Nascent synaptic networks have a high incidence of silent synapses. In this issue of Neuron, Shen et al. show that a brief burst of action potentials rapidly awaken silent synapses by increasing the availability of synaptic vesicles for fusion through BDNF-triggered presynaptic actin remodeling mediated by the small GTPase Cdc42.

摘要

新生的突触网络中沉默突触的发生率很高。在本期《神经元》杂志中，沈等人表明，短暂的动作电位爆发通过小GTP酶Cdc42介导的BDNF触发的突触前肌动蛋白重塑，增加用于融合的突触囊泡的可用性，从而迅速唤醒沉默突触。