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临床死亡模型中大鼠脑和血浆中环磷酸腺苷浓度的变化。

Changes of concentration of cyclic AMP in rat brain and plasma in the clinical death model.

作者信息

Kapuściński A

机构信息

Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.

出版信息

Neuropatol Pol. 1991;29(1-2):95-101.

PMID:1667542
Abstract

In the experimental model of clinical death in rats (Korpachev et al. 1982) cyclic AMP concentrations were evaluated in the brain and plasma at the end of 5-min clinical death, and 5, 15, 30, 60 and 120 min after resuscitation. The cAMP 125I assay system has been used. At the end of clinical death the cAMP level decreased in the brain with normalization 15 min after resuscitation; the second decrease of the cAMP level was observed 30 min post resuscitation with normalization in later periods. In the plasma cAMP concentration did not change at the end of clinical death, followed by a significant increase 5 min after resuscitation. Later the level of plasma cAMP decreased being still above the control value after 2 hours. The possible role of endogenous catecholamines stimulation on adenylate cyclase activity is discussed.

摘要

在大鼠临床死亡实验模型中(科尔帕切夫等人,1982年),在5分钟临床死亡结束时以及复苏后5、15、30、60和120分钟,对大脑和血浆中的环磷酸腺苷(cAMP)浓度进行了评估。使用了cAMP 125I检测系统。临床死亡结束时,大脑中的cAMP水平下降,复苏后15分钟恢复正常;复苏后30分钟观察到cAMP水平再次下降,后期恢复正常。临床死亡结束时血浆中的cAMP浓度没有变化,复苏后5分钟显著升高。之后血浆cAMP水平下降,2小时后仍高于对照值。讨论了内源性儿茶酚胺刺激对腺苷酸环化酶活性的可能作用。

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