Harłozińska A, Bar J K, Gawlikowski W, Richter R, Cisło M
Department of Tumour Immunology, Silesian Piast's Medical Academy, Wrocław, Poland.
Ann Chir Gynaecol. 1991;80(4):368-75.
The levels of CA 125 and carcinoembryonic antigen (CEA) in tumour cyst fluid, ascites and serum of patients with epithelial ovarian neoplasms were estimated. In addition, the serum concentration of both antigens was evaluated 10 days after operation. Independently of histological type of ovarian tumour, CA 125 and CEA values were significantly higher in cyst and ascitic fluid than in corresponding patients' serum. The higher values of both markers were also found in malignant than benign ovarian cysts. CEA occurred at higher concentrations in mucinous carcinomas whereas CA 125 values were comparable both in mucinous and serous cyst fluid. The levels of these markers in cyst fluid did not correlate with the serum concentrations. The significant individual differences existed in the ability of tumour cells to produce and release both studied antigens. Post-operative CEA levels returned to normal more slow than CA 125 values.
对上皮性卵巢肿瘤患者肿瘤囊液、腹水和血清中的CA 125和癌胚抗原（CEA）水平进行了评估。此外，术后10天对两种抗原的血清浓度进行了评估。无论卵巢肿瘤的组织学类型如何，囊液和腹水中的CA 125和CEA值均显著高于相应患者的血清。在恶性卵巢囊肿中也发现这两种标志物的值高于良性囊肿。CEA在黏液性癌中的浓度较高，而CA 125值在黏液性和浆液性囊液中相当。囊液中这些标志物的水平与血清浓度无关。肿瘤细胞产生和释放这两种研究抗原的能力存在显著的个体差异。术后CEA水平恢复正常的速度比CA 125值更慢。
