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1
TREK-1, a K+ channel involved in polymodal pain perception.
EMBO J. 2006 Jun 7;25(11):2368-76. doi: 10.1038/sj.emboj.7601116. Epub 2006 May 4.
2
TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat.
J Pain. 2008 Apr;9(4):298-308. doi: 10.1016/j.jpain.2007.12.001. Epub 2008 Jan 28.
4
Acid sensitivity of the spinal dorsal root ganglia C-fiber nociceptors innervating the guinea pig esophagus.
Neurogastroenterol Motil. 2015 Jun;27(6):865-74. doi: 10.1111/nmo.12561. Epub 2015 Apr 5.
5
The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.
EMBO J. 2009 May 6;28(9):1308-18. doi: 10.1038/emboj.2009.57. Epub 2009 Mar 12.
7
Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Pain. 2014 Dec;155(12):2534-2544. doi: 10.1016/j.pain.2014.09.013. Epub 2014 Sep 18.
10
What is a polymodal nociceptor?
J Pain. 2008 Apr;9(4):309-10. doi: 10.1016/j.jpain.2008.02.001.

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1
TREK-1 and epilepsy: regulating the balance of K and the glutamate release in astrocyte-neuron interactions.
Behav Brain Funct. 2025 Aug 31;21(1):27. doi: 10.1186/s12993-025-00294-x.
2
The research progress into cellular mechanosensitive ion channels mediating cancer pain.
Channels (Austin). 2025 Dec;19(1):2517109. doi: 10.1080/19336950.2025.2517109. Epub 2025 Jun 14.
3
LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening.
Biomolecules. 2025 May 20;15(5):740. doi: 10.3390/biom15050740.
4
Insights into the structure and modulation of human TWIK-2.
bioRxiv. 2025 Feb 24:2025.02.19.639014. doi: 10.1101/2025.02.19.639014.
5
Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation.
Cell Death Dis. 2025 Mar 8;16(1):164. doi: 10.1038/s41419-025-07478-3.
6
7
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator Tool Compound.
ACS Chem Neurosci. 2025 Mar 5;16(5):960-967. doi: 10.1021/acschemneuro.5c00032. Epub 2025 Feb 21.
8
Research progress of TRPV4 in pain over the past 20 years: a bibliometric analysis.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb 14. doi: 10.1007/s00210-025-03846-0.
9
Force versus Response: Methods for Activating and Characterizing Mechanosensitive Ion Channels and GPCRs.
Adv Healthc Mater. 2024 Dec;13(31):e2402167. doi: 10.1002/adhm.202402167. Epub 2024 Oct 14.
10
Unraveling the Molecular Reason of Opposing Effects of α-Mangostin and Norfluoxetine on TREK-2 at the Same Binding Site.
ChemMedChem. 2024 Dec 2;19(23):e202400409. doi: 10.1002/cmdc.202400409. Epub 2024 Oct 21.

本文引用的文献

1
TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.
Am J Physiol Cell Physiol. 2006 Jul;291(1):C138-46. doi: 10.1152/ajpcell.00629.2005. Epub 2006 Feb 22.
2
TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator.
Pain. 2005 Nov;118(1-2):70-9. doi: 10.1016/j.pain.2005.07.016. Epub 2005 Oct 5.
3
Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.
J Biol Chem. 2005 Aug 26;280(34):30175-84. doi: 10.1074/jbc.M503862200. Epub 2005 Jul 8.
5
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK.
J Physiol. 2005 Apr 1;564(Pt 1):103-16. doi: 10.1113/jphysiol.2004.081059. Epub 2005 Jan 27.
6
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.
EMBO J. 2005 Jan 26;24(2):315-24. doi: 10.1038/sj.emboj.7600515. Epub 2004 Dec 16.
7
Voltage-gated sodium channels and pain pathways.
J Neurobiol. 2004 Oct;61(1):55-71. doi: 10.1002/neu.20094.
8
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels.
Nature. 2004 Aug 12;430(7001):748-54. doi: 10.1038/nature02732.
9
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses.
J Neurosci. 2004 Jul 14;24(28):6410-5. doi: 10.1523/JNEUROSCI.1421-04.2004.
10
TREK-1, a K+ channel involved in neuroprotection and general anesthesia.
EMBO J. 2004 Jul 7;23(13):2684-95. doi: 10.1038/sj.emboj.7600234. Epub 2004 Jun 3.

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