先天性溶血性贫血中红细胞果糖-2,6-二磷酸的含量
Erythrocyte fructose 2,6-bisphosphate content in congenital hemolytic anemias.
作者信息
Colomer D, Pujades A, Carballo E, Vives Corrons J L
机构信息
Haematology Laboratory Department, Hospital Clinic i Provinicial, University of Barcelona, Catalonia, Spain.
出版信息
Hemoglobin. 1991;15(6):517-23. doi: 10.3109/03630269109027899.
We have investigated the levels of fructose 2,6-bisphosphate and its synthesizing enzyme 6-phosphofructo-2-kinase in red blood cells from different congenital anemias. Fructose 2,6-bisphosphate concentration and 6-phosphofructo-2-kinase activity are markedly influenced by the number of reticulocytes in all the cases studied with the exception of homozygous pyruvate kinase deficiency, where no correlation was observed with the percentage of reticulocytes.
我们研究了不同先天性贫血患者红细胞中果糖-2,6-二磷酸及其合成酶6-磷酸果糖-2-激酶的水平。除纯合子丙酮酸激酶缺乏症外，在所研究的所有病例中，果糖-2,6-二磷酸浓度和6-磷酸果糖-2-激酶活性均受到网织红细胞数量的显著影响，在纯合子丙酮酸激酶缺乏症中未观察到与网织红细胞百分比的相关性。
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