Monfils M-H, Driscoll I, Melvin N R, Kolb B
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Neuroscience. 2006 Aug 11;141(1):213-21. doi: 10.1016/j.neuroscience.2006.03.047. Epub 2006 May 4.
Basic fibroblast growth factor-2 is a trophic molecule involved in a number of functions within the CNS, including the regulation of CNS responses to injury. Prior studies suggest that rats recover differently from injury inflicted to different regions and at different ages throughout development, and that basic fibroblast growth factor-2 may, at least in part, underlie this phenomenon. In the present study, we describe the distribution of basic fibroblast growth factor-2 at postnatal days 0, 2, 6, 10, 12, 14, 18, 21 and 30 in the indusium griseum, the external capsule, the hippocampus, the medial prefrontal cortex, the motor cortex, the rostral migratory stream, and the subventricular zone. Our results suggest a differential temporal and spatial expression of basic fibroblast growth factor-2 throughout development, which may explain the differential recovery observed from cortical lesions inflicted at different time points after birth.
碱性成纤维细胞生长因子-2是一种营养分子，参与中枢神经系统内的多种功能，包括调节中枢神经系统对损伤的反应。先前的研究表明，大鼠在整个发育过程中，对不同区域和不同年龄所受损伤的恢复情况不同，且碱性成纤维细胞生长因子-2可能至少部分地是这一现象的基础。在本研究中，我们描述了出生后第0、2、6、10、12、14、18、21和30天，在灰被、外囊、海马、内侧前额叶皮质、运动皮质、吻侧迁移流和脑室下区中碱性成纤维细胞生长因子-2的分布。我们的结果表明，碱性成纤维细胞生长因子-2在整个发育过程中存在不同的时空表达，这可能解释了出生后不同时间点造成的皮质损伤所观察到的不同恢复情况。
