Mulkern Robert V, Davis Peter E, Haker Steven J, Estepar Raul San Jose, Panych Lawrence P, Maier Stephan E, Rivkin Michael J
Department of Radiology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Magn Reson Imaging. 2006 May;24(4):463-74. doi: 10.1016/j.mri.2006.01.007. Epub 2006 Mar 6.
Studying the intersection of brain structure and function is an important aspect of modern neuroscience. The development of magnetic resonance imaging (MRI) over the last 25 years has provided new and powerful tools for the study of brain structure and function. Two tools in particular, diffusion imaging and functional MRI (fMRI), are playing increasingly important roles in elucidating the complementary aspects of brain structure and function. In this work, we review basic technical features of diffusion imaging and fMRI for studying the integrity of white matter structural components and for determining the location and extent of cortical activation in gray matter, respectively. We then review a growing body of literature in which the complementary aspects of diffusion imaging and fMRI, applied as separate examinations but analyzed in tandem, have been exploited to enhance our knowledge of brain structure and function.
研究脑结构与功能的交叉领域是现代神经科学的一个重要方面。在过去25年中，磁共振成像（MRI）技术的发展为脑结构与功能的研究提供了全新且强大的工具。尤其是扩散成像和功能磁共振成像（fMRI）这两种工具，在阐明脑结构与功能的互补关系方面正发挥着越来越重要的作用。在本文中，我们分别回顾了扩散成像和fMRI的基本技术特征，它们分别用于研究白质结构成分的完整性以及确定灰质中皮质激活的位置和范围。接着，我们回顾了越来越多的文献，这些文献利用扩散成像和fMRI作为单独检查但串联分析时的互补关系，来增进我们对脑结构与功能的认识。
