钙调神经磷酸酶相互作用蛋白在心肌肥大中的作用
CAMTA in cardiac hypertrophy.
作者信息
Schwartz Robert J, Schneider Michael D
机构信息
The Institute of Biosciences and Technology, The Texas A&M University System Health Science Center, Houston, TX 77030, USA.
出版信息
Cell. 2006 May 5;125(3):427-9. doi: 10.1016/j.cell.2006.04.015.
PMID:16678087
Abstract
In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5.
摘要
在本期《细胞》杂志中，宋等人（2006年）指出钙调蛋白结合转录激活因子2（CAMTA2）是心脏肥大不可或缺的转录共激活因子。CAMTA2通过II类组蛋白去乙酰化酶5的解离而被激活，并通过与Nkx2-5相互作用促进参与心脏肥大的基因转录。
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