Jeltsch Albert, Nellen Wolfgang, Lyko Frank
School of Engineering and Science, International University Bremen, Campus Ring 1, 28759 Bremen, Germany.
Trends Biochem Sci. 2006 Jun;31(6):306-8. doi: 10.1016/j.tibs.2006.04.005. Epub 2006 May 6.
Dnmt2 enzymes have been widely conserved during evolution and contain all of the signature motifs of DNA (cytosine-5)-methyltransferases; however, the DNA methyltransferase activity of these proteins is comparatively weak and their biochemical and functional properties remain enigmatic. Recent evidence now shows that Dnmt2 has a novel tRNA methyltransferase activity, raising the possibility that the biological roles of these proteins might be broader than previously thought. This finding has important implications for understanding the evolutionary relationships among these enzymes.
Dnmt2 酶在进化过程中得到了广泛的保留，并且包含 DNA（胞嘧啶-5）-甲基转移酶的所有特征基序；然而，这些蛋白质的 DNA 甲基转移酶活性相对较弱，其生化和功能特性仍然是个谜。最近的证据表明，Dnmt2 具有一种新的 tRNA 甲基转移酶活性，这增加了这些蛋白质的生物学作用可能比以前认为的更广泛的可能性。这一发现对于理解这些酶之间的进化关系具有重要意义。
