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α-和β-双氢青蒿素二聚体:双(3,6,9-三甲基-3,12-环氧-3,4,5,5a,6,7,8,8a,9,10-十氢-12H-吡喃并[4,3-j][1,2]苯并二氧杂环庚三烯-10-基)醚

A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.

作者信息

Yue Zheng Yu, Li Shu Hui, Gao Po, Zhang Jin Hui, Yan Peng Fei

机构信息

School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China.

出版信息

Acta Crystallogr C. 2006 May;62(Pt 5):o281-2. doi: 10.1107/S0108270106009048. Epub 2006 Apr 13.

Abstract

The title compound, C30H46O9, prepared from a mixture of alpha- and beta-dihydroartemisinin, has alpha- and beta-arteether moieties linked via an -O- bridge, so that the molecule is asymmetric about the bridge. The endoperoxide bridges of the parent compounds have been retained in each half of the ether-bridged dimer. The rings exhibit chair and twist-boat conformations.

摘要

标题化合物C30H46O9由α-和β-二氢青蒿素的混合物制备而成,具有通过-O-桥连接的α-和β-蒿甲醚部分,因此分子关于该桥不对称。母体化合物的内过氧化物桥在醚桥二聚体的每一半中均得以保留。环呈现椅式和扭船式构象。

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