• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

α-和β-双氢青蒿素二聚体：双（3,6,9-三甲基-3,12-环氧-3,4,5,5a,6,7,8,8a,9,10-十氢-12H-吡喃并[4,3-j][1,2]苯并二氧杂环庚三烯-10-基）醚

A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.

作者信息

Yue Zheng Yu, Li Shu Hui, Gao Po, Zhang Jin Hui, Yan Peng Fei

机构信息

School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China.

出版信息

Acta Crystallogr C. 2006 May;62(Pt 5):o281-2. doi: 10.1107/S0108270106009048. Epub 2006 Apr 13.

DOI:10.1107/S0108270106009048
PMID:16679604
Abstract

The title compound, C30H46O9, prepared from a mixture of alpha- and beta-dihydroartemisinin, has alpha- and beta-arteether moieties linked via an -O- bridge, so that the molecule is asymmetric about the bridge. The endoperoxide bridges of the parent compounds have been retained in each half of the ether-bridged dimer. The rings exhibit chair and twist-boat conformations.

摘要

标题化合物C30H46O9由α-和β-二氢青蒿素的混合物制备而成，具有通过-O-桥连接的α-和β-蒿甲醚部分，因此分子关于该桥不对称。母体化合物的内过氧化物桥在醚桥二聚体的每一半中均得以保留。环呈现椅式和扭船式构象。

相似文献

1
A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.α-和β-双氢青蒿素二聚体：双（3,6,9-三甲基-3,12-环氧-3,4,5,5a,6,7,8,8a,9,10-十氢-12H-吡喃并[4,3-j][1,2]苯并二氧杂环庚三烯-10-基）醚
Acta Crystallogr C. 2006 May;62(Pt 5):o281-2. doi: 10.1107/S0108270106009048. Epub 2006 Apr 13.
2
1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane.1,2-双[(3,6,9-三甲基-3,12-环氧-3,4,5,5a,6,7,8,8a,9,10,12,12a-十二氢-吡喃并[4,3-j][1,2]苯并二氧杂环庚三烯-4-基)-氧基]乙烷
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o661. doi: 10.1107/S1600536812005089. Epub 2012 Feb 10.
3
Structure of an ether dimer of deoxydihydroqinghaosu, a potential metabolite of the antimalarial arteether.双氢青蒿素醚二聚体的结构，抗疟药蒿甲醚的一种潜在代谢产物。
Acta Crystallogr C. 1989 Feb 15;45 ( Pt 2):292-4. doi: 10.1107/s0108270188010613.
4
Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity.
Pharm Res. 1993 May;10(5):662-6. doi: 10.1023/a:1018943329109.
5
Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.第二代具有高稳定性、有效性和抗癌活性的口服活性抗疟青蒿素衍生三氧烷二聚体。
J Med Chem. 2006 May 4;49(9):2731-4. doi: 10.1021/jm058288w.
6
Stereochemistry-dependent cytotoxicity of some artemisinin derivatives.某些青蒿素衍生物的立体化学依赖性细胞毒性。
J Nat Prod. 1997 Apr;60(4):325-30. doi: 10.1021/np9605495.
7
Antimalarial peroxide dyads from natural artemisinin and hydroxyalkylated 1,2,4-trioxanes.来自天然青蒿素和羟烷基化1,2,4 - 三氧杂环己烷的抗疟过氧化物二元化合物。
J Med Chem. 2009 May 28;52(10):3420-3. doi: 10.1021/jm9002523.
8
New orally active diphenylmethyl-based ester analogues of dihydroartemisinin: Synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice.新型口服活性二氢青蒿素二苯甲基酯类似物的合成及其对小鼠耐多药约氏疟原虫尼日尔株的抗疟活性评估
Bioorg Med Chem Lett. 2016 Mar 15;26(6):1536-1541. doi: 10.1016/j.bmcl.2016.02.019. Epub 2016 Feb 9.
9
Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation.脱水脱氧二氢青蒿素光氧化制备的脱氧青蒿素衍生物及其细胞毒性评价
J Nat Prod. 2002 Feb;65(2):184-8. doi: 10.1021/np0104065.
10
Saradaferin, a new sesquiterpenoid coumarin from Ferula assafoetida.萨拉达菲林，一种从阿魏中提取的新型倍半萜香豆素。
Nat Prod Res. 2006 Aug;20(10):961-5. doi: 10.1080/14786410600823431.

引用本文的文献

1
Antimalarial activity and metabolism of dihydroartemisinin-derived dimer.双氢青蒿素衍生物二聚体的抗疟活性与代谢
Parasitol Res. 2018 Jul;117(7):2243-2254. doi: 10.1007/s00436-018-5911-x. Epub 2018 May 15.
2
1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane.1,2-双[(3,6,9-三甲基-3,12-环氧-3,4,5,5a,6,7,8,8a,9,10,12,12a-十二氢-吡喃并[4,3-j][1,2]苯并二氧杂环庚三烯-4-基)-氧基]乙烷
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o661. doi: 10.1107/S1600536812005089. Epub 2012 Feb 10.
3
A second polymorph of β-arteether.
β-蒿甲醚的第二种多晶型物。
Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 13;64(Pt 3):o585-6. doi: 10.1107/S1600536807062812.
4
Redetermination of dihydro-artemisinin at 103 (2) K.在103 (2) K温度下对双氢青蒿素进行重新测定。
Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 6;64(Pt 1):o89-90. doi: 10.1107/S1600536807063180.