Logvinenko N S, Khlebodarova T M, Solenov E I, Ivanova L N, Broude N E, Monastyrskaia G S
Tsitologiia. 1991;33(11):18-25.
A study was made of effects of aldosterone, aldosterone+dexamethasone, and aldosterone+spironolactone on Na,K-ATPase mRNA expression in renal cortex of adult and 10 day old rats, when kidney is not sensitive to the hormone injection. It is shown that hormonal induction of synthesis of Na,K-pump mRNA occurs in the early postnatal period apart from mineral corticoid receptors. It seems probable that aldosterone exerts its action in 10 day old rats by interaction with glucocorticoid receptors inducing synthesis of different amounts of alpha- and beta-subunits of Na,K-ATPase.
研究了醛固酮、醛固酮+地塞米松以及醛固酮+螺内酯对成年大鼠和10日龄大鼠肾皮质中钠钾-ATP酶mRNA表达的影响，此时肾脏对激素注射不敏感。结果表明，除盐皮质激素受体外，钠钾泵mRNA合成的激素诱导发生在出生后早期。醛固酮可能通过与糖皮质激素受体相互作用，诱导合成不同量的钠钾-ATP酶α和β亚基，从而在10日龄大鼠中发挥作用。
