Jelic Tomislav M, Berry Paula K, Jubelirer Steven J, Plumley Lisa, Hartel Paul H, Estalilla Oscar C, Chang Ho-Huang
Department of Pathology and Laboratory Medicine, Charleston Area Medical Center, Charleston, West Virginia 25304, USA.
Am J Hematol. 2006 Jun;81(6):448-53. doi: 10.1002/ajh.20572.
We report a reciprocal translocation between the long arms of chromosomes 12 and 21, t(12;21)(q13;q22), in a patient with primary cutaneous follicle center lymphoma. Follicle center lymphoma of the skin and follicle center cell lymphoma of the lymph node are morphologically and immunophenotypically very similar. However, the clinical behavior and prognosis of these tumors are different due to the molecular basis of these malignancies. Follicle center cell lymphoma of the lymph node is determined by the presence of a unique translocation between chromosomes 14 and 18, t(14;18)(q32;q21), BCL-2-JH gene rearrangement, that is not present in primary cutaneous follicle center lymphomas. Chromosomal translocations in the primary skin lymphomas have not been previously reported. We hope that our discovery of a new translocation t(12:21)(q13q22) will encourage further investigation into the molecular basis of this translocation and other cytogenetic abnormalities in primary cutaneous B-cell lymphomas.
我们报告了1例原发性皮肤滤泡中心淋巴瘤患者存在12号和21号染色体长臂之间的相互易位，即t(12;21)(q13;q22)。皮肤滤泡中心淋巴瘤与淋巴结滤泡中心细胞淋巴瘤在形态学和免疫表型上非常相似。然而，由于这些恶性肿瘤的分子基础，这些肿瘤的临床行为和预后有所不同。淋巴结滤泡中心细胞淋巴瘤由14号和18号染色体之间独特的易位t(14;18)(q32;q21)、BCL-2-JH基因重排所决定，而原发性皮肤滤泡中心淋巴瘤不存在这种情况。原发性皮肤淋巴瘤中的染色体易位此前尚未见报道。我们希望我们发现的新易位t(12:21)(q13q22)将促使人们进一步研究这种易位以及原发性皮肤B细胞淋巴瘤中其他细胞遗传学异常的分子基础。
