Schüller H M
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
Cancer Cells. 1991 Dec;3(12):496-503.
Most lung cancers are simultaneously stimulated by several autocrine and paracrine growth factors. Diseases resulting in excessive production of these factors and/or changes in the receptors, second messengers, or genes comprising their signal transduction pathways can thus result in the stimulation of continuous cell proliferation characteristic of cancer. Some carcinogenic N-nitrosamines mimic the stimulatory effect of cell-type-specific growth factors by binding to their receptors, and in this way mediate their selective carcinogenic effects. In this review I discuss the significance of receptor-mediated mitogenic signal transduction pathways for the initiation and progression of lung cancer, and describe novel lung cancer therapeutics that target components of these pathways.
大多数肺癌同时受到多种自分泌和旁分泌生长因子的刺激。导致这些因子过度产生和/或其受体、第二信使或构成其信号转导途径的基因发生变化的疾病，可能会刺激癌细胞特有的持续细胞增殖。一些致癌性N-亚硝胺通过与细胞类型特异性生长因子的受体结合，模拟其刺激作用，从而介导其选择性致癌作用。在这篇综述中，我讨论了受体介导的促有丝分裂信号转导途径对肺癌发生和发展的意义，并描述了针对这些途径成分的新型肺癌治疗方法。
