Benbenisty Keith M, Andea Aleodor, Metcalf John, Cook Joel
Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Dermatol Surg. 2006 Apr;32(4):582-7; discussion 587. doi: 10.1111/j.1524-4725.2006.32120.x.
Atypical cellular neurothekeoma is a rare neoplasm generally regarded as a benign tumor with locally aggressive behavior. Recurrence is common with inadequate excision, but metastatic disease has yet to be reported.
The objective was to report a case of atypical cellular neurothekeoma of the nasal ala in a young woman treated by Mohs micrographic surgery. The biologic behavior and histopathology will be reviewed.
Case report and review of the literature.
The neoplasm was extirpated in a three-stage, five section Mohs surgery procedure. The resulting defect was repaired by a two-stage, pedicled nasolabial transposition flap with a cartilage graft taken from the ipsilateral ear. No clinical recurrence was noted after 6-months of follow-up.
Mohs micrographic surgery is unsurpassed in its efficacy in treating a wide variety of nonmelanoma skin cancers. Although most commonly used to address basal and squamous cell carcinoma, it has also been reported as a successful treatment for melanoma and a wide variety of cutaneous malignancies. We discuss a case of atypical cellular neurothekeoma removed with the Mohs technique. Debate in the literature is ongoing regarding the true histogenesis of this rare tumor. Because of this tumor's local destructive behavior and propensity to recur with inadequate resection, we recommend Moths micrographic surgery for the treatment of cellular neurothekeomas.
非典型细胞性神经鞘黏液瘤是一种罕见肿瘤，通常被视为具有局部侵袭性行为的良性肿瘤。切除不充分时复发很常见，但转移性疾病尚未见报道。
报告一例采用莫氏显微外科手术治疗的年轻女性鼻翼非典型细胞性神经鞘黏液瘤病例，并对其生物学行为和组织病理学进行回顾。
病例报告及文献复习。
该肿瘤通过三阶段、五切片的莫氏手术切除。 resulting defect应改为The resulting defect，意为“ resulting defect”（此处可能有误，推测应为“所形成的缺损”），通过两阶段带蒂鼻唇转位皮瓣修复，并取自同侧耳软骨移植。随访6个月后未发现临床复发。
莫氏显微外科手术在治疗多种非黑色素瘤皮肤癌方面疗效无与伦比。尽管最常用于治疗基底细胞癌和鳞状细胞癌，但也有报道称其对黑色素瘤和多种皮肤恶性肿瘤治疗成功。我们讨论一例采用莫氏技术切除的非典型细胞性神经鞘黏液瘤病例。关于这种罕见肿瘤的真正组织发生学，文献中的争论仍在继续。由于这种肿瘤具有局部破坏行为且切除不充分时易复发，我们建议采用莫氏显微外科手术治疗细胞性神经鞘黏液瘤。
原文中“resulting defect”可能表述有误，推测正确表述应为“所形成的缺损”，以上翻译按照推测意思进行了调整。
