Seay Montrell, Patel Shalaka, Dinesh-Kumar Savithramma P
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.
Cell Microbiol. 2006 Jun;8(6):899-906. doi: 10.1111/j.1462-5822.2006.00715.x.
Plant innate immunity is often associated with specialized programmed cell death at or near the site of pathogen infection. Despite the isolation of several lesion mimic mutants, the molecular mechanisms that regulate cell death during an immune response remain obscure. Recently, autophagy, an evolutionarily conserved process of bulk protein and organelle turnover, was shown to play an important role in limiting cell death initiated during plant innate immune responses. Consistent with its role in plants, several studies in animals also demonstrate that the autophagic machinery is involved in innate as well as adaptive immunities. Here, we review the role of autophagy in plant innate immunity. Because autophagy is observed in healthy and dying plant cells, we will also examine whether autophagy plays a protective or a destructive role during an immune response.
植物先天免疫通常与病原体感染部位或其附近的特异性程序性细胞死亡相关。尽管已分离出多个类病斑突变体，但免疫反应过程中调节细胞死亡的分子机制仍不清楚。最近，自噬作为一种进化上保守的大量蛋白质和细胞器周转过程，被证明在限制植物先天免疫反应引发的细胞死亡中起重要作用。与其在植物中的作用一致，动物中的几项研究也表明，自噬机制参与先天免疫和适应性免疫。在这里，我们综述自噬在植物先天免疫中的作用。由于在健康和濒死的植物细胞中都观察到了自噬，我们还将研究自噬在免疫反应过程中是起保护作用还是破坏作用。
