Ozdemir Ismail, Demirci Fuat, Yucel Oguz, Erkorkmaz Unal
Department of Obstetrics and Gynecology, Abant Izzet Baysal University, Duzce Medical School, 81620 Konuralp, Duzce, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2007 Feb;130(2):176-9. doi: 10.1016/j.ejogrb.2006.03.021. Epub 2006 May 8.
To compare cervical length measurements at 10-14 and 20-24 weeks gestation in asymptomatic women with singleton pregnancies and to assess the measurements as a predictor of preterm delivery.
In this prospective study, cervical length was measured in 152 asymptomatic women with singleton pregnancies using transvaginal ultrasonography at 10-14 and 20-24 weeks gestation. The primary outcome measure was spontaneous preterm delivery before 35 weeks of gestation. The mean cervical length was calculated at both stages, and lengths were compared between the term and preterm groups.
The rate of spontaneous preterm deliveries was 10.5%. The mean cervical length at 10-14 and 20-24 weeks was 40.5 and 37.1mm, respectively. The cervical length at 10-14 weeks was not significantly different between those who delivered at term (40.9 mm) and those who delivered preterm (38.6 mm). By contrast, the cervical length at 20-24 weeks was significantly shorter in the group that had preterm deliveries (28.4 mm) than in those who had term deliveries (37.8 mm) (P < 0.001). The cervical shortening was more apparent in the group that delivered prematurely (from 38.6 to 28.4 mm) than in that which delivered at term (from 40.9 to 37.8 mm).
Cervical length measurement used to predict preterm delivery was found to be more predictive at 20-24 weeks. Cervical length measurement at 10-14 weeks was not reliable for predicting preterm delivery. The mean cervical length tapered gradually from the first to the second scan, and the more rapid cervical shortening was found to be associated with increased risk for preterm delivery.
比较单胎妊娠无症状女性在妊娠10 - 14周和20 - 24周时的宫颈长度测量值，并评估这些测量值作为早产预测指标的情况。
在这项前瞻性研究中，对152名单胎妊娠无症状女性在妊娠10 - 14周和20 - 24周时使用经阴道超声测量宫颈长度。主要结局指标是妊娠35周前的自发早产。计算两个阶段的平均宫颈长度，并比较足月分娩组和早产组之间的长度。
自发早产率为10.5%。妊娠10 - 14周和20 - 24周时的平均宫颈长度分别为40.5毫米和37.1毫米。足月分娩者（40.9毫米）和早产者（38.6毫米）在妊娠10 - 14周时的宫颈长度无显著差异。相比之下，早产组在妊娠20 - 24周时的宫颈长度（28.4毫米）明显短于足月分娩组（37.8毫米）（P < 0.001）。早产组的宫颈缩短（从38.6毫米至28.4毫米）比足月分娩组（从40.9毫米至37.8毫米）更明显。
发现用于预测早产的宫颈长度测量在20 - 24周时预测性更强。妊娠10 - 14周时的宫颈长度测量对预测早产不可靠。从第一次扫描到第二次扫描，平均宫颈长度逐渐变窄，且发现宫颈缩短越快与早产风险增加相关。
