Amundadottir Laufey T, Sulem Patrick, Gudmundsson Julius, Helgason Agnar, Baker Adam, Agnarsson Bjarni A, Sigurdsson Asgeir, Benediktsdottir Kristrun R, Cazier Jean-Baptiste, Sainz Jesus, Jakobsdottir Margret, Kostic Jelena, Magnusdottir Droplaug N, Ghosh Shyamali, Agnarsson Kari, Birgisdottir Birgitta, Le Roux Louise, Olafsdottir Adalheidur, Blondal Thorarinn, Andresdottir Margret, Gretarsdottir Olafia Svandis, Bergthorsson Jon T, Gudbjartsson Daniel, Gylfason Arnaldur, Thorleifsson Gudmar, Manolescu Andrei, Kristjansson Kristleifur, Geirsson Gudmundur, Isaksson Helgi, Douglas Julie, Johansson Jan-Erik, Bälter Katarina, Wiklund Fredrik, Montie James E, Yu Xiaoying, Suarez Brian K, Ober Carole, Cooney Kathleen A, Gronberg Henrik, Catalona William J, Einarsson Gudmundur V, Barkardottir Rosa B, Gulcher Jeffrey R, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
Nat Genet. 2006 Jun;38(6):652-8. doi: 10.1038/ng1808. Epub 2006 May 7.
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
随着前列腺癌发病率的不断上升，识别导致该疾病风险的常见基因变异至关重要。在此，我们报告了位于8号染色体q24区域的这样一种变异，该区域最初是通过对冰岛家族的研究确定的。微卫星DG8S737的 -8等位基因在来自冰岛、瑞典和美国的三个欧洲血统病例对照系列中与前列腺癌相关。该等位基因的估计比值比（OR）为1.62（P = 2.7×10⁻¹¹）。约19%的患癌男性和13%的普通人群携带至少一个拷贝，产生的人群归因风险（PAR）约为8%。这种关联在一个具有相似OR的非裔美国病例对照组中也得到了重复，其中41%的患病人群和30%的普通人群是携带者。这导致估计的PAR更高（16%），这可能是导致非裔美国男性前列腺癌发病率高于欧洲血统男性的原因。
