Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub M P, Chambon P
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France.
C R Seances Soc Biol Fil. 1991;185(6):391-401.
Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.
急性早幼粒细胞白血病的特征是t(15;17)染色体易位，这导致了早幼粒细胞白血病蛋白（PML，位于15号染色体）和维甲酸受体α（RAR-α，位于17号染色体）之间形成融合产物。我们描述了两类具有不同的PML-RAR和RAR-PML融合转录本的患者。然后我们讨论了PML的功能特性，并表明PML-RAR可干扰PML和RAR-α的功能。
