Wang Ting-Ting, Li Ke, Wei Lei
Department of Pathophysiology ,Medical College of Wuhan University, Wuhan 430071, China.
Sheng Li Ke Xue Jin Zhan. 2006 Jan;37(1):27-30.
Regulation of cytoskeletal dynamics is required to coordinate cell adhesion, morphology change and cell motility. Vasodilator-stimulated phosphoprotein (VASP) is an actin-binding protein which is composed of EVH1, EVH2 domains and PRR. It has been implicated in actin-based processes such as axon guidance, T cell polarization and fibroblast migrations. The regulation of VASP phosphorylation, which is controlled by PKG (cGMP-dependent protein kinase) and PKA (cAMP-dependent protein kinase), could correspond to the "switch" process in its communication with cytoskeleton during modification of focal adhesion.
细胞骨架动力学的调控对于协调细胞黏附、形态变化和细胞运动是必需的。血管舒张刺激磷蛋白（VASP）是一种肌动蛋白结合蛋白，由EVH1、EVH2结构域和PRR组成。它参与了基于肌动蛋白的过程，如轴突导向、T细胞极化和成纤维细胞迁移。VASP磷酸化的调控由PKG（环磷酸鸟苷依赖性蛋白激酶）和PKA（环磷酸腺苷依赖性蛋白激酶）控制，这可能对应于其在粘着斑修饰过程中与细胞骨架通讯的“开关”过程。
