Jones A K, Liyi Q, Cunningham V V, Brown D W, Ha-Kawa S, Fujiwara T, Friston K F, Silva S, Luthra S K, Jones T
Medical Research Council Cycloton Unit, Hammersmith Hospital, London, England.
Int J Clin Pharmacol Res. 1991;11(6):261-6.
Identification of the main areas in the brain that respond specifically to the "suffering" components of pain has been achieved by using serial dynamic measurements of blood flow as an index of synaptic activity. Specific response to a repeated painful thermal stimulus as compared to a non-painful thermal stimulus in normal male volunteers identified the anterior cingulate cortex and the thalamus contralateral to the side of stimulation as the main sites of significant response. It was concluded that it was these areas where pain was likely to be experienced. Changes in opioid receptor binding in the brain was measured using 11C-diprenorphine and positron emission tomography in three patients with rheumatoid arthritis. In the two patients with active rheumatoid arthritis substantial changes in opioid receptor binding in the brain are described. The significance of these findings are discussed.
通过将血流的连续动态测量作为突触活动的指标，已确定大脑中对疼痛的“痛苦”成分有特异性反应的主要区域。在正常男性志愿者中，与非疼痛热刺激相比，对重复疼痛热刺激的特异性反应确定前扣带回皮质和刺激侧对侧的丘脑为显著反应的主要部位。得出的结论是，这些区域可能是体验疼痛的地方。使用11C - 二丙诺啡和正电子发射断层扫描技术测量了三名类风湿性关节炎患者大脑中阿片受体结合的变化。描述了两名活动性类风湿性关节炎患者大脑中阿片受体结合的实质性变化。讨论了这些发现的意义。
